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Acupuncture Knee Arthritis Cartilage Repair Discovery

Acupuncture stimulates knee osteoarthritis cartilage repair by regulating proteins TGF-β1 and IGF-1. Beijing University of Traditional Chinese medicine researchers determined that acupuncture accelerates articular cartilage repair in the osteoarthritic knee by inhibiting the overexpression of TGF-β1 and IGF-1. With multiple objective laboratory instruments measuring outcomes, the investigation also reveal that acupuncture smooths the surface of knee cartilage while regulating cell proliferation and differentiation. [1] Under the results section of this article, you will be able to read more about this groundbreaking discovery. Knee osteoarthritis (KOA) often presents with pain, limited mobility, and a reduction in quality of life. Pathologically, it is characterized by changes in the articular cartilage, the subchondral bone, the intra-articular space, ligaments, and the articular capsule region. The researchers designed a laboratory experiment to determine the biochemical mechanisms by which acupuncture exerts its therapeutic actions. The randomized study of 30 experimental rabbits was divided into three arms: a control group (n=10), a knee osteoarthritis model group (n=10), and an acupuncture treatment group (n=10). For the KOA model group and treatment group, a KOA model was made by immobilization of the rabbit knee. Only the treatment group received warm needle acupuncture treatments. The control group did not receive any medical procedures or treatment for the duration of the study. ResultsThe hospital researchers conclude, “In comparison with the control group, the expression levels of both TGF-beta1 [transforming growth factor beta 1] and IGF1 [insulin-like growth factor 1] were up-regulated in the KOA model group and then down-regulated after the warm-needling treatment.” They add that both microscopic and macroscopic improvements in the knee joint were observed. After the treatment, “the surface of knee cartilage became smoother.” Additionally, “less abnormal cell proliferations and clusters were found in the warm-needling group compared to those of the model group.” The research team determined that “acupuncture can inhibit the overexpression of TGF-beta1 and IGF-1 in the knee cartilage of rabbits with KOA, having a solid effect in improving pathological changes of knee cartilage.” Acupuncture Acupuncture treatment commenced one week after the KOA model was established. Acupuncture was applied once per day, for a total of four weeks. Needle retention time per acupuncture session was 20 minutes. Manual needle stimulation was applied to elicit a deqi response for each needle. Additionally, moxa cuttings were attached to each needle handle and ignited for 20 minutes to warm the needles. The acupoints used in the study were the following:

  • EX-LE4 (Neixiyan, medial Xiyan)

  • EX-LE5 (Waixiyan, lateral Xiyan)

  • SP10 (Xuehai)

  • GB34 (Yanglingquan)

The researchers note that Traditional Chinese Medicine (TCM) principles were used to make the acupoint selection for the study. This acupoint prescription is widely used on human patients. In Traditional Chinese Medicine, KOA is in the scope of Gu Bi (translated as bone impediment) and Xi Tong (translated as knee pain). The stagnation of external pernicious influences (e.g., wind, cold, damp, heat, phlegm) in the local meridians (acupuncture channels and collaterals) is a primary cause of KOA. The TCM treatment principle is to invigorate local blood circulation and disperse stagnation. Neixiyan, Waixiyan, Xuehai, and Yanglingquan are located at the knee region. Needling these acupoints accelerates local blood circulation. According to the Huangdi Neijing (The Yellow Emperor’s Classic of Medicine), “the knee is the house of the tendons.” Yanglingquan (GB34) is the gathering point of the tendons. Needling this acupoint treats tendon issues, including those related to the knee joint. In this study, moxibustion was also applied as a part of warm needling therapy. Moxibustion warms the local area and supplements acupuncture to promote blood circulation and disperse stagnation. Laboratory DetectionThe researchers note, “KOA is caused by an imbalance between knee cartilage degradation and repair, the process of which is closely related to TGF-beta1 and IGF-1.” [1] This is supported by another research investigation, in which Stephen et al. concluded that “TGF-beta1 and IGF-1 plays an important role in cartilage homeostasis.” [2] TGF-beta1 is a secreted protein involved in osteoblast formation and bone remodeling. There is a positive correlation between the concentration of TGF-beta1 and the degree of cartilage damage. Fahlgren et al. note that “high concentrations of TGF-beta1 in synovial lavage fluid seemed indicative for the later development of more severe OA changes in contrast t